Drug interactions
Dexamethasone-tobramycin + Tezacaftor
Severity: Moderate
Dexamethasone-tobramycin and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tezacaftor is a CYP3A substrate, and dexamethasone may induce CYP3A4 and lower its exposure. The inducer effect is weaker than strong inducers, for which the label advises avoidance.
What this interaction means in plain words
Dexamethasone-tobramycin and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by dexamethasone increases tezacaftor metabolism.
What to do
Monitor clinical response with prolonged systemic dexamethasone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Frequently asked questions
Can I take Dexamethasone-tobramycin with Tezacaftor?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tezacaftor is a CYP3A substrate, and dexamethasone may induce CYP3A4 and lower its exposure. The inducer effect is weaker than strong inducers, for which the label advises avoidance.
How serious is the interaction between Dexamethasone-tobramycin and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response with prolonged systemic dexamethasone.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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