Drug interactions
Dexamethasone-tobramycin + Tofacitinib
Severity: Moderate
Dexamethasone-tobramycin and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic dexamethasone adds to the immunosuppression of tofacitinib and raises the risk of serious infection. Topical or ophthalmic dexamethasone adds little systemic immunosuppression.
What this interaction means in plain words
Dexamethasone-tobramycin and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Tofacitinib belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic immunosuppression from corticosteroid and JAK inhibition.
What to do
With systemic corticosteroids, use the lowest effective dose and monitor for infection. Topical use needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Tofacitinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Dexamethasone-tobramycin with Tofacitinib?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic dexamethasone adds to the immunosuppression of tofacitinib and raises the risk of serious infection. Topical or ophthalmic dexamethasone adds little systemic immunosuppression.
How serious is the interaction between Dexamethasone-tobramycin and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic corticosteroids, use the lowest effective dose and monitor for infection. Topical use needs no change.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
