Drug interactions
Dexamethasone-tobramycin + Typhoid vaccine live
Severity: Minor
Dexamethasone-tobramycin and Typhoid vaccine live: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live oral typhoid vaccine (Ty21a) is a live bacterial vaccine whose replication is reduced by antibacterial agents, and corticosteroid immunosuppression may also lower the response. Tobramycin is an aminoglycoside with minimal systemic and gut exposure when used topically, so the effect is likely limited.
What this interaction means in plain words
Dexamethasone-tobramycin and Typhoid vaccine live have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Antibacterials may inhibit the live attenuated bacteria, and corticosteroids may blunt the immune response, though topical use gives low systemic exposure.
What to do
For topical use, no change is usually needed. If systemic antibiotics are given, delay the live typhoid vaccine until antibiotic therapy is complete, or use the injectable polysaccharide vaccine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexamethasone-tobramycin and Typhoid vaccine live, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Frequently asked questions
Can I take Dexamethasone-tobramycin with Typhoid vaccine live?
MediHelp rates the interaction as minor. Dexamethasone-tobramycin and Typhoid vaccine live have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Live oral typhoid vaccine (Ty21a) is a live bacterial vaccine whose replication is reduced by antibacterial agents, and corticosteroid immunosuppression may also lower the response. Tobramycin is an aminoglycoside with minimal systemic and gut exposure when used topically, so the effect is likely limited.
How serious is the interaction between Dexamethasone-tobramycin and Typhoid vaccine live?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For topical use, no change is usually needed. If systemic antibiotics are given, delay the live typhoid vaccine until antibiotic therapy is complete, or use the injectable polysaccharide vaccine.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
