Drug interactions
Dexamethasone-tobramycin + Ulipristal
Severity: Moderate
Dexamethasone-tobramycin and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal is metabolized by CYP3A4, and CYP3A4 inducers can reduce its levels and weaken emergency contraception. Dexamethasone is a weaker inducer than agents such as rifampin, but a reduction in efficacy is possible with systemic use.
What this interaction means in plain words
Dexamethasone-tobramycin and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by dexamethasone increases ulipristal metabolism.
What to do
Consider a copper intrauterine device or levonorgestrel at an appropriate dose if systemic dexamethasone is being taken long term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Frequently asked questions
Can I take Dexamethasone-tobramycin with Ulipristal?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ulipristal is metabolized by CYP3A4, and CYP3A4 inducers can reduce its levels and weaken emergency contraception. Dexamethasone is a weaker inducer than agents such as rifampin, but a reduction in efficacy is possible with systemic use.
How serious is the interaction between Dexamethasone-tobramycin and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a copper intrauterine device or levonorgestrel at an appropriate dose if systemic dexamethasone is being taken long term.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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