Drug interactions
Dexfenfluramine + Dextroamphetamine
Severity: Major
Dexfenfluramine and Dextroamphetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs release serotonin and have sympathomimetic effects. Together they may cause serotonin syndrome, hypertension and tachycardia. Dexfenfluramine was withdrawn because of valvular heart disease and pulmonary hypertension, so combined use is not appropriate.
What this interaction means in plain words
Dexfenfluramine and Dextroamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonin and catecholamine release producing serotonergic and sympathomimetic toxicity.
What to do
Avoid the combination. If exposure has occurred, monitor blood pressure, heart rate and signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dexfenfluramine with Dextroamphetamine?
MediHelp rates the interaction as major. Dexfenfluramine and Dextroamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs release serotonin and have sympathomimetic effects. Together they may cause serotonin syndrome, hypertension and tachycardia. Dexfenfluramine was withdrawn because of valvular heart disease and pulmonary hypertension, so combined use is not appropriate.
How serious is the interaction between Dexfenfluramine and Dextroamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If exposure has occurred, monitor blood pressure, heart rate and signs of serotonin toxicity.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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