Drug interactions
Dexfenfluramine + Epinephrine
Severity: Moderate
Dexfenfluramine and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine is a serotonergic anorectic, and with epinephrine there may be additive increases in blood pressure and heart rate. The evidence for a sympathomimetic interaction is limited, and the drug is withdrawn in most markets.
What this interaction means in plain words
Dexfenfluramine and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive sympathomimetic and serotonergic cardiovascular effects; mechanism not firmly established.
What to do
Monitor blood pressure and heart rate if epinephrine is given systemically. Use the lowest effective epinephrine dose in hypertensive patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexfenfluramine and Epinephrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Dexfenfluramine with Epinephrine?
MediHelp rates the interaction as moderate. Dexfenfluramine and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine is a serotonergic anorectic, and with epinephrine there may be additive increases in blood pressure and heart rate. The evidence for a sympathomimetic interaction is limited, and the drug is withdrawn in most markets.
How serious is the interaction between Dexfenfluramine and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate if epinephrine is given systemically. Use the lowest effective epinephrine dose in hypertensive patients.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
