Drug interactions
Dexfenfluramine + Insulin lispro
Severity: Moderate
Dexfenfluramine and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine has been reported to improve glucose uptake and insulin sensitivity, which could increase hypoglycemia risk with insulin. The drug has been withdrawn from most markets.
What this interaction means in plain words
Dexfenfluramine and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased peripheral glucose uptake and insulin sensitivity add to the effect of insulin.
What to do
If the drug is encountered, monitor blood glucose closely and reduce the insulin lispro dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Frequently asked questions
Can I take Dexfenfluramine with Insulin lispro?
MediHelp rates the interaction as moderate. Dexfenfluramine and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine has been reported to improve glucose uptake and insulin sensitivity, which could increase hypoglycemia risk with insulin. The drug has been withdrawn from most markets.
How serious is the interaction between Dexfenfluramine and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the drug is encountered, monitor blood glucose closely and reduce the insulin lispro dose as required.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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