Drug interactions
Dextroamphetamine + Diethylpropion
Severity: Moderate
Dextroamphetamine and Diethylpropion: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sympathomimetic stimulants, so combining them produces additive increases in blood pressure, heart rate and central nervous system stimulation. This raises the risk of hypertension, tachyarrhythmia, anxiety and insomnia without added therapeutic benefit.
What this interaction means in plain words
Dextroamphetamine and Diethylpropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic sympathomimetic effects through enhanced release of norepinephrine and dopamine.
What to do
Avoid using two stimulant anorectic or ADHD agents together where possible. If co-administered, monitor blood pressure and heart rate and reduce or stop one agent if cardiovascular symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Diethylpropion?
MediHelp rates the interaction as moderate. Dextroamphetamine and Diethylpropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sympathomimetic stimulants, so combining them produces additive increases in blood pressure, heart rate and central nervous system stimulation. This raises the risk of hypertension, tachyarrhythmia, anxiety and insomnia without added therapeutic benefit.
How serious is the interaction between Dextroamphetamine and Diethylpropion?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two stimulant anorectic or ADHD agents together where possible. If co-administered, monitor blood pressure and heart rate and reduce or stop one agent if cardiovascular symptoms occur.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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