Drug interactions
Dextroamphetamine + Diphenhydramine
Severity: Minor
Dextroamphetamine and Diphenhydramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenhydramine causes sedation that dextroamphetamine may partly oppose, and the stimulant may mask drowsiness without removing impairment. Combined use is generally well tolerated.
What this interaction means in plain words
Dextroamphetamine and Diphenhydramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Diphenhydramine belongs to Respiratory.
Why it happens
Opposing central nervous system effects (H1 antagonism versus amphetamine-induced monoamine release).
What to do
No action beyond awareness is usually required. Counsel patients about residual impairment and watch for tachycardia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Diphenhydramine
Frequently asked questions
Can I take Dextroamphetamine with Diphenhydramine?
MediHelp rates the interaction as minor. Dextroamphetamine and Diphenhydramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diphenhydramine causes sedation that dextroamphetamine may partly oppose, and the stimulant may mask drowsiness without removing impairment. Combined use is generally well tolerated.
How serious is the interaction between Dextroamphetamine and Diphenhydramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action beyond awareness is usually required. Counsel patients about residual impairment and watch for tachycardia.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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