Drug interactions
Dextroamphetamine + Epinephrine inhaled
Severity: Minor
Dextroamphetamine and Epinephrine inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled epinephrine has limited but real systemic absorption, and with amphetamine the adrenergic effects may add up. This may cause increased heart rate, blood pressure and palpitations, mainly in patients with cardiovascular disease.
What this interaction means in plain words
Dextroamphetamine and Epinephrine inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive sympathomimetic effects from direct adrenergic agonism and amphetamine-induced catecholamine release.
What to do
Use inhaled epinephrine at recommended doses and monitor heart rate and blood pressure in patients with cardiovascular disease. Reassess if palpitations or chest pain occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Epinephrine inhaled?
MediHelp rates the interaction as minor. Dextroamphetamine and Epinephrine inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Inhaled epinephrine has limited but real systemic absorption, and with amphetamine the adrenergic effects may add up. This may cause increased heart rate, blood pressure and palpitations, mainly in patients with cardiovascular disease.
How serious is the interaction between Dextroamphetamine and Epinephrine inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use inhaled epinephrine at recommended doses and monitor heart rate and blood pressure in patients with cardiovascular disease. Reassess if palpitations or chest pain occur.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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