Drug interactions
Dextroamphetamine + Epinephrine racemic
Severity: Moderate
Dextroamphetamine and Epinephrine racemic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Racemic epinephrine inhalation delivers some systemic adrenergic stimulation, and amphetamine adds indirect sympathomimetic effects. The combination can increase heart rate and blood pressure and may provoke arrhythmias in susceptible patients.
What this interaction means in plain words
Dextroamphetamine and Epinephrine racemic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic effects from direct adrenergic agonism and amphetamine-induced catecholamine release.
What to do
Monitor heart rate and blood pressure during and after treatment, particularly in children with cardiac risk factors. Use the lowest effective epinephrine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Epinephrine racemic?
MediHelp rates the interaction as moderate. Dextroamphetamine and Epinephrine racemic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Racemic epinephrine inhalation delivers some systemic adrenergic stimulation, and amphetamine adds indirect sympathomimetic effects. The combination can increase heart rate and blood pressure and may provoke arrhythmias in susceptible patients.
How serious is the interaction between Dextroamphetamine and Epinephrine racemic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure during and after treatment, particularly in children with cardiac risk factors. Use the lowest effective epinephrine dose.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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