Drug interactions
Dextroamphetamine + Epinephrine
Severity: Moderate
Dextroamphetamine and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs stimulate the sympathetic system, so combined use can produce marked increases in blood pressure and heart rate and may provoke arrhythmias. Amphetamine-induced norepinephrine release may amplify the cardiovascular response to epinephrine.
What this interaction means in plain words
Dextroamphetamine and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Epinephrine belongs to Endocrine.
Why it happens
Additive adrenergic stimulation: direct receptor agonism by epinephrine and indirect catecholamine release by amphetamine.
What to do
Monitor blood pressure, heart rate and ECG when epinephrine is given to a patient on dextroamphetamine. Do not withhold epinephrine in anaphylaxis, but use the lowest effective dose and for local anesthetic mixtures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Dextroamphetamine with Epinephrine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs stimulate the sympathetic system, so combined use can produce marked increases in blood pressure and heart rate and may provoke arrhythmias. Amphetamine-induced norepinephrine release may amplify the cardiovascular response to epinephrine.
How serious is the interaction between Dextroamphetamine and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when epinephrine is given to a patient on dextroamphetamine. Do not withhold epinephrine in anaphylaxis, but use the lowest effective dose and for local anesthetic mixtures.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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