Drug interactions
Dextroamphetamine + Esketamine
Severity: Moderate
Dextroamphetamine and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise blood pressure and heart rate, so together they may produce larger cardiovascular responses. Patients with hypertension or cardiac disease are at greater risk.
What this interaction means in plain words
Dextroamphetamine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Additive sympathomimetic cardiovascular stimulation.
What to do
Check blood pressure before dosing and about 40 minutes after, and defer esketamine if baseline pressure is elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Esketamine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs raise blood pressure and heart rate, so together they may produce larger cardiovascular responses. Patients with hypertension or cardiac disease are at greater risk.
How serious is the interaction between Dextroamphetamine and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure before dosing and about 40 minutes after, and defer esketamine if baseline pressure is elevated.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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