Drug interactions
Dextroamphetamine + Ioflupane i
Severity: Moderate
Dextroamphetamine and Ioflupane i: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamine binds to the dopamine transporter, the target of ioflupane I-123, and may reduce or alter tracer uptake in DaTscan imaging. This could lead to misinterpretation of the scan.
What this interaction means in plain words
Dextroamphetamine and Ioflupane i can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive binding at the striatal dopamine transporter, reducing ioflupane binding.
What to do
Check the imaging center's guidance and, where clinically feasible, withhold amphetamine for an appropriate period before the scan, taking into account its half-life. Interpret results cautiously if the drug cannot be stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Ioflupane i?
MediHelp rates the interaction as moderate. Dextroamphetamine and Ioflupane i can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamine binds to the dopamine transporter, the target of ioflupane I-123, and may reduce or alter tracer uptake in DaTscan imaging. This could lead to misinterpretation of the scan.
How serious is the interaction between Dextroamphetamine and Ioflupane i?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the imaging center's guidance and, where clinically feasible, withhold amphetamine for an appropriate period before the scan, taking into account its half-life. Interpret results cautiously if the drug cannot be stopped.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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