Drug interactions
Dextroamphetamine + Isoniazid
Severity: Moderate
Dextroamphetamine and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid has weak monoamine oxidase inhibitory activity, which could theoretically potentiate the pressor and serotonergic effects of amphetamines. Clinically significant reactions are rarely reported. Patients may experience palpitations, hypertension or agitation.
What this interaction means in plain words
Dextroamphetamine and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak MAO inhibition by isoniazid may increase amphetamine-induced monoamine release effects.
What to do
Monitor blood pressure, heart rate and for agitation or serotonin toxicity symptoms. Reduce the amphetamine dose or stop it if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Isoniazid?
MediHelp rates the interaction as moderate. Dextroamphetamine and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid has weak monoamine oxidase inhibitory activity, which could theoretically potentiate the pressor and serotonergic effects of amphetamines. Clinically significant reactions are rarely reported. Patients may experience palpitations, hypertension or agitation.
How serious is the interaction between Dextroamphetamine and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and for agitation or serotonin toxicity symptoms. Reduce the amphetamine dose or stop it if symptoms occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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