Drug interactions
Dextroamphetamine + Lansoprazole
Severity: Minor
Dextroamphetamine and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elevated gastric pH from a PPI can shift the timing of amphetamine absorption, particularly with some extended-release products, with earlier peak concentrations. Overall exposure is unchanged, so the effect is small.
What this interaction means in plain words
Dextroamphetamine and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH alters release or absorption rate of amphetamine formulations without changing total exposure.
What to do
No dose change is needed; watch for earlier onset of stimulant effects or insomnia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Lansoprazole?
MediHelp rates the interaction as minor. Dextroamphetamine and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elevated gastric pH from a PPI can shift the timing of amphetamine absorption, particularly with some extended-release products, with earlier peak concentrations. Overall exposure is unchanged, so the effect is small.
How serious is the interaction between Dextroamphetamine and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; watch for earlier onset of stimulant effects or insomnia.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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