Drug interactions
Dextroamphetamine + Levorphanol
Severity: Minor
Dextroamphetamine and Levorphanol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamine can partially counteract opioid sedation and may enhance opioid analgesia, and can mask signs of opioid excess. Respiratory depression may recur or become apparent when the stimulant effect fades.
What this interaction means in plain words
Dextroamphetamine and Levorphanol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing central nervous system effects; the analgesic potentiation mechanism is not well established.
What to do
Titrate levorphanol according to respiratory rate and pain relief rather than alertness. Monitor respiratory status when stimulant effects wear off.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Levorphanol?
MediHelp rates the interaction as minor. Dextroamphetamine and Levorphanol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amphetamine can partially counteract opioid sedation and may enhance opioid analgesia, and can mask signs of opioid excess. Respiratory depression may recur or become apparent when the stimulant effect fades.
How serious is the interaction between Dextroamphetamine and Levorphanol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate levorphanol according to respiratory rate and pain relief rather than alertness. Monitor respiratory status when stimulant effects wear off.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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