Drug interactions
Dextroamphetamine + Lofepramine
Severity: Major
Dextroamphetamine and Lofepramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic that blocks norepinephrine reuptake and is partly metabolized to desipramine. Combined with amphetamine it may produce exaggerated or unpredictable sympathomimetic effects such as hypertension, tachycardia and arrhythmia.
What this interaction means in plain words
Dextroamphetamine and Lofepramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Blocked norepinephrine reuptake gives additive adrenergic effects, and the tricyclic may alter neuronal uptake of amphetamine.
What to do
Prefer an alternative combination. If used together, monitor blood pressure, heart rate and ECG and titrate doses slowly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dextroamphetamine and Lofepramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Lofepramine?
MediHelp rates the interaction as major. Dextroamphetamine and Lofepramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lofepramine is a tricyclic that blocks norepinephrine reuptake and is partly metabolized to desipramine. Combined with amphetamine it may produce exaggerated or unpredictable sympathomimetic effects such as hypertension, tachycardia and arrhythmia.
How serious is the interaction between Dextroamphetamine and Lofepramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative combination. If used together, monitor blood pressure, heart rate and ECG and titrate doses slowly.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
