Drug interactions
Dextroamphetamine + Lsd
Severity: Moderate
Dextroamphetamine and Lsd: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a serotonergic psychedelic and amphetamine increases serotonin and catecholamine release, so the combination may intensify psychological and sympathomimetic effects. Anxiety, agitation, tachycardia, hypertension and hyperthermia may result.
What this interaction means in plain words
Dextroamphetamine and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and sympathomimetic effects via 5-HT2A agonism and monoamine release.
What to do
Advise against use of LSD with amphetamines and monitor vital signs and mental state if exposure has occurred. Provide supportive care for agitation or hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Lsd?
MediHelp rates the interaction as moderate. Dextroamphetamine and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD is a serotonergic psychedelic and amphetamine increases serotonin and catecholamine release, so the combination may intensify psychological and sympathomimetic effects. Anxiety, agitation, tachycardia, hypertension and hyperthermia may result.
How serious is the interaction between Dextroamphetamine and Lsd?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against use of LSD with amphetamines and monitor vital signs and mental state if exposure has occurred. Provide supportive care for agitation or hyperthermia.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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