Drug interactions
Dextroamphetamine + Lumefantrine
Severity: Moderate
Dextroamphetamine and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is a CYP2D6 inhibitor and dextroamphetamine is partly cleared by this pathway, so amphetamine exposure may rise modestly. This could increase stimulant effects such as tachycardia, hypertension, agitation and insomnia.
What this interaction means in plain words
Dextroamphetamine and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6 by lumefantrine may reduce the hepatic metabolism of dextroamphetamine.
What to do
Monitor heart rate, blood pressure and CNS stimulation during the short antimalarial course. Reduce the dextroamphetamine dose if excessive stimulant effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dextroamphetamine and Lumefantrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Lumefantrine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is a CYP2D6 inhibitor and dextroamphetamine is partly cleared by this pathway, so amphetamine exposure may rise modestly. This could increase stimulant effects such as tachycardia, hypertension, agitation and insomnia.
How serious is the interaction between Dextroamphetamine and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and CNS stimulation during the short antimalarial course. Reduce the dextroamphetamine dose if excessive stimulant effects appear.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
