Drug interactions
Dextroamphetamine + Methylenedioxymethamphetamine
Severity: Major
Dextroamphetamine and Methylenedioxymethamphetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA and dextroamphetamine both strongly increase monoamine release, leading to additive hypertension, tachycardia, hyperthermia and agitation. Serotonin toxicity and arrhythmia are possible, particularly with high doses or in hot environments.
What this interaction means in plain words
Dextroamphetamine and Methylenedioxymethamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive monoamine release and reuptake inhibition, with amplified sympathomimetic and serotonergic effects.
What to do
Advise strict avoidance of MDMA during amphetamine therapy. Treat hyperthermia, severe hypertension or serotonin toxicity as emergencies.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Methylenedioxymethamphetamine?
MediHelp rates the interaction as major. Dextroamphetamine and Methylenedioxymethamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MDMA and dextroamphetamine both strongly increase monoamine release, leading to additive hypertension, tachycardia, hyperthermia and agitation. Serotonin toxicity and arrhythmia are possible, particularly with high doses or in hot environments.
How serious is the interaction between Dextroamphetamine and Methylenedioxymethamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise strict avoidance of MDMA during amphetamine therapy. Treat hyperthermia, severe hypertension or serotonin toxicity as emergencies.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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