Drug interactions
Dextroamphetamine + Nefazodone
Severity: Moderate
Dextroamphetamine and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines promote release of serotonin and norepinephrine, and nefazodone adds serotonergic activity, so serotonin syndrome is possible. Nefazodone also inhibits CYP3A4 and may modestly raise amphetamine exposure.
What this interaction means in plain words
Dextroamphetamine and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects, with minor pharmacokinetic contribution from CYP3A4 inhibition.
What to do
Monitor for agitation, tremor, hyperthermia, tachycardia and hypertension, especially after starting or raising doses. Reduce the amphetamine dose if excessive stimulation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Nefazodone?
MediHelp rates the interaction as moderate. Dextroamphetamine and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines promote release of serotonin and norepinephrine, and nefazodone adds serotonergic activity, so serotonin syndrome is possible. Nefazodone also inhibits CYP3A4 and may modestly raise amphetamine exposure.
How serious is the interaction between Dextroamphetamine and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, tachycardia and hypertension, especially after starting or raising doses. Reduce the amphetamine dose if excessive stimulation occurs.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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