Drug interactions
Dextroamphetamine + Olanzapine
Severity: Moderate
Dextroamphetamine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine blocks dopamine and serotonin receptors and may reduce the effects of amphetamine, while stimulants can worsen psychotic symptoms. Their sedative and alerting effects also oppose each other.
What this interaction means in plain words
Dextroamphetamine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine receptors and opposing CNS effects.
What to do
Monitor psychiatric symptoms, sedation and heart rate, and reassess the stimulant if psychosis worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Dextroamphetamine with Olanzapine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine blocks dopamine and serotonin receptors and may reduce the effects of amphetamine, while stimulants can worsen psychotic symptoms. Their sedative and alerting effects also oppose each other.
How serious is the interaction between Dextroamphetamine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric symptoms, sedation and heart rate, and reassess the stimulant if psychosis worsens.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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