Drug interactions
Dextroamphetamine + Pentobarbital
Severity: Moderate
Dextroamphetamine and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital is a sedative-hypnotic and dextroamphetamine is a stimulant, so their CNS effects oppose one another unpredictably. Stimulation can mask barbiturate sedation, and barbiturate enzyme induction may also modestly alter drug exposure.
What this interaction means in plain words
Dextroamphetamine and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS pharmacodynamic effects; barbiturate hepatic enzyme induction may also contribute.
What to do
Monitor level of consciousness and respiratory status objectively. Adjust doses based on clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Pentobarbital?
MediHelp rates the interaction as moderate. Dextroamphetamine and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital is a sedative-hypnotic and dextroamphetamine is a stimulant, so their CNS effects oppose one another unpredictably. Stimulation can mask barbiturate sedation, and barbiturate enzyme induction may also modestly alter drug exposure.
How serious is the interaction between Dextroamphetamine and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of consciousness and respiratory status objectively. Adjust doses based on clinical response.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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