Drug interactions
Dextroamphetamine + Pholcodine
Severity: Minor
Dextroamphetamine and Pholcodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pholcodine is an opioid antitussive with mild sedative properties, while dextroamphetamine is stimulating. The effects oppose each other, and any interaction is expected to be minor at antitussive doses.
What this interaction means in plain words
Dextroamphetamine and Pholcodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS pharmacodynamic effects; no pharmacokinetic mechanism is established.
What to do
No dose adjustment is usually needed. Counsel patients about variable alertness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Pholcodine?
MediHelp rates the interaction as minor. Dextroamphetamine and Pholcodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pholcodine is an opioid antitussive with mild sedative properties, while dextroamphetamine is stimulating. The effects oppose each other, and any interaction is expected to be minor at antitussive doses.
How serious is the interaction between Dextroamphetamine and Pholcodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Counsel patients about variable alertness.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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