Drug interactions
Dextroamphetamine + Pimozide
Severity: Major
Dextroamphetamine and Pimozide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide is a potent dopamine antagonist that can counter amphetamine effects, and stimulants may exacerbate tics, which pimozide treats. Pimozide also markedly prolongs the QT interval, and stimulant-induced tachycardia may add to arrhythmia risk.
What this interaction means in plain words
Dextroamphetamine and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dextroamphetamine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Dopaminergic antagonism opposing stimulant action, plus additive cardiac effects with QT prolongation.
What to do
Avoid if possible; if combined, obtain a baseline and follow-up ECG and monitor tics, heart rate and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Pimozide?
MediHelp rates the interaction as major. Dextroamphetamine and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pimozide is a potent dopamine antagonist that can counter amphetamine effects, and stimulants may exacerbate tics, which pimozide treats. Pimozide also markedly prolongs the QT interval, and stimulant-induced tachycardia may add to arrhythmia risk.
How serious is the interaction between Dextroamphetamine and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if combined, obtain a baseline and follow-up ECG and monitor tics, heart rate and electrolytes.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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