Drug interactions
Dextroamphetamine + Pirbuterol
Severity: Moderate
Dextroamphetamine and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine releases catecholamines and, with a beta-agonist like pirbuterol, can produce additive increases in heart rate and blood pressure. Patients may experience palpitations, tremor, anxiety or arrhythmias, especially with cardiac disease.
What this interaction means in plain words
Dextroamphetamine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic effects from amphetamine-induced catecholamine release plus direct beta-adrenergic agonism.
What to do
Monitor heart rate, blood pressure and symptoms of excessive adrenergic stimulation. Use the lowest effective doses and avoid in patients with significant cardiovascular disease where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Pirbuterol?
MediHelp rates the interaction as moderate. Dextroamphetamine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine releases catecholamines and, with a beta-agonist like pirbuterol, can produce additive increases in heart rate and blood pressure. Patients may experience palpitations, tremor, anxiety or arrhythmias, especially with cardiac disease.
How serious is the interaction between Dextroamphetamine and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and symptoms of excessive adrenergic stimulation. Use the lowest effective doses and avoid in patients with significant cardiovascular disease where possible.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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