Drug interactions
Dextroamphetamine + Rabeprazole
Severity: Minor
Dextroamphetamine and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lower gastric acidity can speed up dextroamphetamine absorption from certain formulations, shortening the time to peak concentration. Overall exposure is unchanged, so the effect is small.
What this interaction means in plain words
Dextroamphetamine and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH alters release from pH-dependent amphetamine formulations, changing absorption rate but not extent.
What to do
No dose adjustment is usually needed; observe for earlier onset of stimulant effects with extended-release products.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Rabeprazole?
MediHelp rates the interaction as minor. Dextroamphetamine and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lower gastric acidity can speed up dextroamphetamine absorption from certain formulations, shortening the time to peak concentration. Overall exposure is unchanged, so the effect is small.
How serious is the interaction between Dextroamphetamine and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; observe for earlier onset of stimulant effects with extended-release products.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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