Drug interactions
Dextroamphetamine + Sodium citrate / citric acid
Severity: Moderate
Dextroamphetamine and Sodium citrate / citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium citrate is metabolized to bicarbonate and can raise urinary pH, which slows the renal excretion of amphetamines. This may prolong and intensify dextroamphetamine effects and increase adverse cardiovascular and CNS stimulation.
What this interaction means in plain words
Dextroamphetamine and Sodium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Citrate-induced urinary alkalinization increases the non-ionized fraction of dextroamphetamine, increasing tubular reabsorption and lowering renal clearance.
What to do
Monitor blood pressure, heart rate and clinical response when the combination is used regularly. Reduce the dextroamphetamine dose if signs of excess stimulation develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dextroamphetamine and Sodium citrate / citric acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Sodium citrate / citric acid?
MediHelp rates the interaction as moderate. Dextroamphetamine and Sodium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium citrate is metabolized to bicarbonate and can raise urinary pH, which slows the renal excretion of amphetamines. This may prolong and intensify dextroamphetamine effects and increase adverse cardiovascular and CNS stimulation.
How serious is the interaction between Dextroamphetamine and Sodium citrate / citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and clinical response when the combination is used regularly. Reduce the dextroamphetamine dose if signs of excess stimulation develop.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
