Drug interactions
Dextroamphetamine + Sufentanil sl
Severity: Moderate
Dextroamphetamine and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines have serotonergic activity and opioids such as sufentanil have been rarely linked with serotonin syndrome. Concurrent use could therefore increase the risk of agitation, tremor, hyperthermia and autonomic instability.
What this interaction means in plain words
Dextroamphetamine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity from amphetamine-induced serotonin release and opioid effects on serotonin transmission.
What to do
Monitor for signs of serotonin syndrome, especially at initiation and dose increases. Stop the serotonergic agents if features of toxicity appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Sufentanil sl?
MediHelp rates the interaction as moderate. Dextroamphetamine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines have serotonergic activity and opioids such as sufentanil have been rarely linked with serotonin syndrome. Concurrent use could therefore increase the risk of agitation, tremor, hyperthermia and autonomic instability.
How serious is the interaction between Dextroamphetamine and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome, especially at initiation and dose increases. Stop the serotonergic agents if features of toxicity appear.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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