Drug interactions
Dextroamphetamine + Sumatriptan intranasal
Severity: Moderate
Dextroamphetamine and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic or adrenergic activity, so concurrent use may rarely cause serotonin syndrome. Amphetamines can also raise blood pressure and add to triptan vasoconstrictive effects.
What this interaction means in plain words
Dextroamphetamine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects (5-HT1B/1D agonism plus amphetamine-induced serotonin release) and additive pressor effects.
What to do
Counsel patients about serotonin syndrome symptoms and monitor blood pressure. Stop the combination if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Dextroamphetamine and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic or adrenergic activity, so concurrent use may rarely cause serotonin syndrome. Amphetamines can also raise blood pressure and add to triptan vasoconstrictive effects.
How serious is the interaction between Dextroamphetamine and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about serotonin syndrome symptoms and monitor blood pressure. Stop the combination if symptoms develop.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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