Drug interactions
Dextroamphetamine + Venlafaxine
Severity: Moderate
Dextroamphetamine and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonin-norepinephrine reuptake inhibitor with an amphetamine can raise the risk of serotonin toxicity and add to cardiovascular stimulation such as raised blood pressure and heart rate. Venlafaxine may also modestly raise amphetamine exposure through CYP2D6 inhibition, although this effect is weak.
What this interaction means in plain words
Dextroamphetamine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive serotonergic and noradrenergic effects, with weak venlafaxine inhibition of CYP2D6-mediated amphetamine metabolism.
What to do
Monitor blood pressure, heart rate and for signs of serotonin toxicity (agitation, tremor, hyperthermia, clonus), especially after dose changes. Reduce the dose or stop one agent if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Venlafaxine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonin-norepinephrine reuptake inhibitor with an amphetamine can raise the risk of serotonin toxicity and add to cardiovascular stimulation such as raised blood pressure and heart rate. Venlafaxine may also modestly raise amphetamine exposure through CYP2D6 inhibition, although this effect is weak.
How serious is the interaction between Dextroamphetamine and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and for signs of serotonin toxicity (agitation, tremor, hyperthermia, clonus), especially after dose changes. Reduce the dose or stop one agent if symptoms appear.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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