Drug interactions
Dextroamphetamine transdermal + Vitamin c
Severity: Moderate
Dextroamphetamine transdermal and Vitamin c: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ascorbic acid in large doses can acidify the urine, which increases renal excretion of amphetamines and may reduce their effect. The effect is most relevant with high-dose vitamin C.
What this interaction means in plain words
Dextroamphetamine transdermal and Vitamin c can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Urinary acidification ionizes amphetamine and reduces renal tubular reabsorption, increasing clearance.
What to do
Avoid high-dose vitamin C or acidifying agents during amphetamine therapy. Reassess clinical response and adjust the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vitamin c
Frequently asked questions
Can I take Dextroamphetamine transdermal with Vitamin c?
MediHelp rates the interaction as moderate. Dextroamphetamine transdermal and Vitamin c can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ascorbic acid in large doses can acidify the urine, which increases renal excretion of amphetamines and may reduce their effect. The effect is most relevant with high-dose vitamin C.
How serious is the interaction between Dextroamphetamine transdermal and Vitamin c?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid high-dose vitamin C or acidifying agents during amphetamine therapy. Reassess clinical response and adjust the dose if needed.
What other medicines interact with Vitamin c?
MediHelp also lists interactions of Vitamin c with, for example, Deferoxamine, Aluminum hydroxide, Aspirin / citric acid / sodium bicarbonate. The full list is on the Vitamin c page.
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