Drug interactions
Dextromoramide + Dimenhydrinate
Severity: Major
Dextromoramide and Dimenhydrinate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating antihistamine with a potent opioid analgesic increases drowsiness, psychomotor impairment and the risk of respiratory depression. Anticholinergic effects may also add to constipation and urinary retention.
What this interaction means in plain words
Dextromoramide and Dimenhydrinate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism plus H1-antihistamine sedation, with additive anticholinergic effects.
What to do
Avoid the combination where possible; if it is needed, use the lowest effective doses and monitor sedation and respiratory rate. Counsel the patient to avoid driving and alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Dextromoramide with Dimenhydrinate?
MediHelp rates the interaction as major. Dextromoramide and Dimenhydrinate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a sedating antihistamine with a potent opioid analgesic increases drowsiness, psychomotor impairment and the risk of respiratory depression. Anticholinergic effects may also add to constipation and urinary retention.
How serious is the interaction between Dextromoramide and Dimenhydrinate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is needed, use the lowest effective doses and monitor sedation and respiratory rate. Counsel the patient to avoid driving and alcohol.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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