Drug interactions
Dextrose + Dichlorphenamide
Severity: Moderate
Dextrose and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous dextrose stimulates insulin release, which shifts potassium into cells and lowers serum potassium. With dichlorphenamide, which also reduces potassium, hypokalemia may be more likely.
What this interaction means in plain words
Dextrose and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextrose belongs to Gastrointestinal Tract; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Insulin-mediated intracellular potassium shift added to dichlorphenamide-induced renal potassium loss.
What to do
Monitor serum potassium when giving large dextrose loads to patients on dichlorphenamide. Supplement potassium if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dextrose with Dichlorphenamide?
MediHelp rates the interaction as moderate. Dextrose and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous dextrose stimulates insulin release, which shifts potassium into cells and lowers serum potassium. With dichlorphenamide, which also reduces potassium, hypokalemia may be more likely.
How serious is the interaction between Dextrose and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when giving large dextrose loads to patients on dichlorphenamide. Supplement potassium if levels fall.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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