Drug interactions
Diamorphine + Triprolidine
Severity: Major
Diamorphine and Triprolidine: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diamorphine (heroin) is a potent opioid, and sedating antihistamines intensify its CNS depressant effects. The combination raises the risk of deep sedation, respiratory depression and coma.
What this interaction means in plain words
Diamorphine and Triprolidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism and H1 antihistamine sedation.
What to do
Avoid if possible and choose a non-sedating antihistamine. If used together, use the lowest effective doses and monitor sedation and respiratory rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Triprolidine
Frequently asked questions
Can I take Diamorphine with Triprolidine?
MediHelp rates the interaction as major. Diamorphine and Triprolidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diamorphine (heroin) is a potent opioid, and sedating antihistamines intensify its CNS depressant effects. The combination raises the risk of deep sedation, respiratory depression and coma.
How serious is the interaction between Diamorphine and Triprolidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose a non-sedating antihistamine. If used together, use the lowest effective doses and monitor sedation and respiratory rate.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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