Drug interactions
Diazepam intranasal + Lansoprazole
Severity: Moderate
Diazepam intranasal and Lansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lansoprazole can inhibit CYP2C19, which helps clear diazepam and its active metabolite. Exposure to diazepam may increase, with more sedation and psychomotor impairment, though the effect is generally modest.
What this interaction means in plain words
Diazepam intranasal and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lansoprazole inhibits CYP2C19-mediated demethylation of diazepam, slowing its elimination.
What to do
Monitor for excess sedation and respiratory depression, particularly in elderly patients or when other CNS depressants are used. Reduce diazepam dosing if sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Diazepam intranasal with Lansoprazole?
MediHelp rates the interaction as moderate. Diazepam intranasal and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lansoprazole can inhibit CYP2C19, which helps clear diazepam and its active metabolite. Exposure to diazepam may increase, with more sedation and psychomotor impairment, though the effect is generally modest.
How serious is the interaction between Diazepam intranasal and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression, particularly in elderly patients or when other CNS depressants are used. Reduce diazepam dosing if sedation develops.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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