Drug interactions
Diazepam intranasal + Rabeprazole
Severity: Minor
Diazepam intranasal and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam is partly cleared by CYP2C19, which rabeprazole inhibits only weakly. Diazepam exposure may rise slightly, with possible added sedation.
What this interaction means in plain words
Diazepam intranasal and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP2C19 inhibition by rabeprazole reduces diazepam clearance.
What to do
Monitor for excess sedation and respiratory depression; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Diazepam intranasal with Rabeprazole?
MediHelp rates the interaction as minor. Diazepam intranasal and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diazepam is partly cleared by CYP2C19, which rabeprazole inhibits only weakly. Diazepam exposure may rise slightly, with possible added sedation.
How serious is the interaction between Diazepam intranasal and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression; no routine dose change is needed.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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