Drug interactions
Dichlorphenamide + Donepezil
Severity: Moderate
Dichlorphenamide and Donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide commonly causes hypokalemia, which increases susceptibility to QT prolongation and arrhythmia. Donepezil can prolong the QT interval, so low potassium could raise the risk of torsades de pointes.
What this interaction means in plain words
Dichlorphenamide and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Donepezil belongs to Central Nervous System.
Why it happens
Carbonic anhydrase inhibitor-induced potassium loss combined with donepezil's QT-prolonging effect.
What to do
Monitor serum potassium and bicarbonate regularly and correct deficits promptly. Consider an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Donepezil?
MediHelp rates the interaction as moderate. Dichlorphenamide and Donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide commonly causes hypokalemia, which increases susceptibility to QT prolongation and arrhythmia. Donepezil can prolong the QT interval, so low potassium could raise the risk of torsades de pointes.
How serious is the interaction between Dichlorphenamide and Donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly and correct deficits promptly. Consider an ECG if other QT risk factors are present.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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