Drug interactions
Dichlorphenamide + Doxorubicin
Severity: Moderate
Dichlorphenamide and Doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes renal potassium loss and metabolic acidosis. Doxorubicin has no established direct potassium-lowering effect, although vomiting and diarrhea from chemotherapy may contribute to hypokalemia. Low potassium may worsen arrhythmia risk in patients with anthracycline cardiotoxicity.
What this interaction means in plain words
Dichlorphenamide and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Doxorubicin belongs to Oncology.
Why it happens
Dichlorphenamide-induced renal potassium wasting combined with chemotherapy-related gastrointestinal losses.
What to do
Check serum potassium and bicarbonate at baseline and periodically, and replace potassium as needed. Take particular care in patients with cardiac impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Doxorubicin?
MediHelp rates the interaction as moderate. Dichlorphenamide and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes renal potassium loss and metabolic acidosis. Doxorubicin has no established direct potassium-lowering effect, although vomiting and diarrhea from chemotherapy may contribute to hypokalemia. Low potassium may worsen arrhythmia risk in patients with anthracycline cardiotoxicity.
How serious is the interaction between Dichlorphenamide and Doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and bicarbonate at baseline and periodically, and replace potassium as needed. Take particular care in patients with cardiac impairment.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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