Drug interactions
Dichlorphenamide + Epinephrine
Severity: Moderate
Dichlorphenamide and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine shifts potassium into cells through beta-2 stimulation and can transiently lower serum potassium, adding to the potassium-lowering effect of dichlorphenamide. The effect is mostly relevant with systemic or repeated doses.
What this interaction means in plain words
Dichlorphenamide and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Epinephrine belongs to Endocrine.
Why it happens
Beta-2 mediated intracellular potassium shift added to renal potassium loss from carbonic anhydrase inhibition.
What to do
Monitor serum potassium when systemic epinephrine is used repeatedly or by infusion. Replace potassium if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Dichlorphenamide with Epinephrine?
MediHelp rates the interaction as moderate. Dichlorphenamide and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine shifts potassium into cells through beta-2 stimulation and can transiently lower serum potassium, adding to the potassium-lowering effect of dichlorphenamide. The effect is mostly relevant with systemic or repeated doses.
How serious is the interaction between Dichlorphenamide and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when systemic epinephrine is used repeatedly or by infusion. Replace potassium if levels fall.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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