Drug interactions
Dichlorphenamide + Etoposide
Severity: Moderate
Dichlorphenamide and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes bicarbonate loss and metabolic acidosis, and etoposide has been associated with metabolic acidosis, especially at high doses. Using them together may worsen acid-base status.
What this interaction means in plain words
Dichlorphenamide and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Etoposide belongs to Oncology.
Why it happens
Additive pharmacodynamic tendency toward metabolic acidosis; carbonic anhydrase inhibition with etoposide-related acidosis.
What to do
Check serum bicarbonate before and periodically during combined therapy. Reduce or discontinue dichlorphenamide if persistent acidosis occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Etoposide?
MediHelp rates the interaction as moderate. Dichlorphenamide and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide causes bicarbonate loss and metabolic acidosis, and etoposide has been associated with metabolic acidosis, especially at high doses. Using them together may worsen acid-base status.
How serious is the interaction between Dichlorphenamide and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum bicarbonate before and periodically during combined therapy. Reduce or discontinue dichlorphenamide if persistent acidosis occurs.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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