Drug interactions
Dichlorphenamide + Formoterol
Severity: Moderate
Dichlorphenamide and Formoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes renal potassium wasting and metabolic acidosis, and formoterol can further lower serum potassium. The combination may produce significant hypokalemia, which can precipitate arrhythmias and muscle weakness.
What this interaction means in plain words
Dichlorphenamide and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Formoterol belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2 mediated intracellular potassium shift and carbonic anhydrase inhibitor-induced renal potassium loss.
What to do
Monitor serum potassium and bicarbonate at baseline and regularly during combined use, and replace potassium as needed. Reassess therapy if hypokalemia or acidosis persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Formoterol?
MediHelp rates the interaction as moderate. Dichlorphenamide and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes renal potassium wasting and metabolic acidosis, and formoterol can further lower serum potassium. The combination may produce significant hypokalemia, which can precipitate arrhythmias and muscle weakness.
How serious is the interaction between Dichlorphenamide and Formoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and regularly during combined use, and replace potassium as needed. Reassess therapy if hypokalemia or acidosis persists.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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