Drug interactions
Dichlorphenamide + Hydrocortisone
Severity: Moderate
Dichlorphenamide and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower serum potassium, so together hypokalemia can be more pronounced. This can cause weakness, arrhythmia and worsen periodic paralysis.
What this interaction means in plain words
Dichlorphenamide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Hydrocortisone belongs to Endocrine.
Why it happens
Additive potassium wasting via renal bicarbonate/potassium loss and mineralocorticoid effect.
What to do
Check serum potassium at baseline and periodically, and supplement potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Hydrocortisone?
MediHelp rates the interaction as moderate. Dichlorphenamide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower serum potassium, so together hypokalemia can be more pronounced. This can cause weakness, arrhythmia and worsen periodic paralysis.
How serious is the interaction between Dichlorphenamide and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium at baseline and periodically, and supplement potassium as needed.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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