Drug interactions
Dichlorphenamide + Insulin nph
Severity: Moderate
Dichlorphenamide and Insulin nph: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Insulin NPH promotes cellular potassium uptake and can lower serum potassium, while dichlorphenamide causes urinary potassium wasting. Combined use can lead to significant hypokalemia.
What this interaction means in plain words
Dichlorphenamide and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from insulin-mediated potassium shift into cells and carbonic anhydrase inhibitor-induced kaliuresis.
What to do
Monitor serum potassium regularly and give potassium supplementation if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Insulin nph?
MediHelp rates the interaction as moderate. Dichlorphenamide and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Insulin NPH promotes cellular potassium uptake and can lower serum potassium, while dichlorphenamide causes urinary potassium wasting. Combined use can lead to significant hypokalemia.
How serious is the interaction between Dichlorphenamide and Insulin nph?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and give potassium supplementation if levels fall.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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