Drug interactions
Dichlorphenamide + Isoniazid
Severity: Moderate
Dichlorphenamide and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause metabolic acidosis, so combined use may worsen acid-base disturbance. This matters most in patients with renal impairment or other acidosis risk factors.
What this interaction means in plain words
Dichlorphenamide and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Isoniazid belongs to Anti Bacterial.
Why it happens
Additive metabolic acidosis from carbonic anhydrase inhibition and isoniazid toxicity.
What to do
Monitor serum bicarbonate and electrolytes at baseline and periodically. Reduce the dichlorphenamide dose or stop one drug if acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Isoniazid?
MediHelp rates the interaction as moderate. Dichlorphenamide and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause metabolic acidosis, so combined use may worsen acid-base disturbance. This matters most in patients with renal impairment or other acidosis risk factors.
How serious is the interaction between Dichlorphenamide and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate and electrolytes at baseline and periodically. Reduce the dichlorphenamide dose or stop one drug if acidosis develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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