Drug interactions
Dichlorphenamide + Metformin-sitagliptin
Severity: Moderate
Dichlorphenamide and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis. Combined with metformin, which can cause lactic acidosis, the risk of serious acid-base disturbance is increased.
What this interaction means in plain words
Dichlorphenamide and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Additive acidosis: carbonic anhydrase inhibition causes bicarbonate loss while metformin promotes lactate accumulation.
What to do
Monitor serum bicarbonate and renal function at baseline and periodically; consider stopping metformin or dichlorphenamide if persistent acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Dichlorphenamide and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis. Combined with metformin, which can cause lactic acidosis, the risk of serious acid-base disturbance is increased.
How serious is the interaction between Dichlorphenamide and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate and renal function at baseline and periodically; consider stopping metformin or dichlorphenamide if persistent acidosis develops.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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