Drug interactions
Dichlorphenamide + Metformin
Severity: Moderate
Dichlorphenamide and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis. Combined with metformin, which carries a risk of lactic acidosis, acid-base disturbance may be amplified.
What this interaction means in plain words
Dichlorphenamide and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Metformin belongs to Endocrine.
Why it happens
Additive acidosis risk from carbonic anhydrase inhibition and metformin-related lactate accumulation.
What to do
Monitor serum bicarbonate and renal function regularly, and review the combination if bicarbonate falls. Stop or reduce therapy if persistent acidosis or symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Metformin?
MediHelp rates the interaction as moderate. Dichlorphenamide and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis. Combined with metformin, which carries a risk of lactic acidosis, acid-base disturbance may be amplified.
How serious is the interaction between Dichlorphenamide and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate and renal function regularly, and review the combination if bicarbonate falls. Stop or reduce therapy if persistent acidosis or symptoms develop.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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