Drug interactions
Dichlorphenamide + Methyclothiazide
Severity: Moderate
Dichlorphenamide and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics promote renal potassium loss, and dichlorphenamide also lowers potassium. Combined use can cause substantial hypokalemia with risk of weakness and arrhythmia.
What this interaction means in plain words
Dichlorphenamide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive kaliuresis from thiazide-induced distal sodium delivery and carbonic anhydrase inhibition.
What to do
Monitor serum potassium and bicarbonate regularly and supplement potassium or adjust therapy when levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Methyclothiazide?
MediHelp rates the interaction as moderate. Dichlorphenamide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics promote renal potassium loss, and dichlorphenamide also lowers potassium. Combined use can cause substantial hypokalemia with risk of weakness and arrhythmia.
How serious is the interaction between Dichlorphenamide and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly and supplement potassium or adjust therapy when levels fall.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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