Drug interactions
Dichlorphenamide + Nitroprusside
Severity: Moderate
Dichlorphenamide and Nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroprusside releases cyanide, and with prolonged or high-dose infusion cyanide toxicity can cause lactic metabolic acidosis. Dichlorphenamide-induced bicarbonate loss reduces buffering capacity, so acidosis may be harder to compensate and recognize.
What this interaction means in plain words
Dichlorphenamide and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive metabolic acidosis from carbonic anhydrase inhibition and potential cyanide-related lactic acidosis.
What to do
Monitor acid-base status and lactate during nitroprusside infusion, using the lowest effective dose and shortest duration. Consider an alternative vasodilator if acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Nitroprusside?
MediHelp rates the interaction as moderate. Dichlorphenamide and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroprusside releases cyanide, and with prolonged or high-dose infusion cyanide toxicity can cause lactic metabolic acidosis. Dichlorphenamide-induced bicarbonate loss reduces buffering capacity, so acidosis may be harder to compensate and recognize.
How serious is the interaction between Dichlorphenamide and Nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor acid-base status and lactate during nitroprusside infusion, using the lowest effective dose and shortest duration. Consider an alternative vasodilator if acidosis develops.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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